A Bayesian mixed modeling approach for estimating heritability

Abstract Background A Bayesian mixed model approach using integrated nested Laplace approximations (INLA) allows us to construct flexible models that can account for pedigree structure.Using these models, we estimate genome-wide patterns of DNA methylation heritability (h 2 ), which are currently not well understood, as well as h 2 of blood lipid m

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Partial protective effect of CCR5-Delta 32 heterozygosity in a cohort of heterosexual Italian HIV-1 exposed uninfected individuals

Abstract Despite multiple sexual exposure to HIV-1 virus, some individuals remain HIV-1 seronegative (exposed seronegative, ESN).The mechanisms underlying this resistance remain still unclear, although a multifactorial pathogenesis can be hypothesised.Although several genetic factors have been related to HIV-1 resistance, the homozigosity for a mut

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The impact of redeployment during COVID-19 on nurse well-being, performance and retention: a mixed-methods study (REDEPLOY)

Background Mass redeployment of nurses was critical to the National Health Service response to COVID-19.There remains little understanding of how redeployment was enacted during the pandemic and its impact on nurse managers’ and nurses’ mental health and well-being, job performance and retention.This study aimed to understand how nurse redeploy

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The History of Paulina

Carmen Chamizo Vega is a point of reference in Spanish Nursing and more concretely in the History of Nursing.Her teaching, care and research labour will lochby venture pouch continue marking the future as well as her untiring work by establishing networks and communication links among scholars of Nursing in Spain and America.Carmen, in a discreet a

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